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When someone takes benzodiazepines including Xanax, the body absorbs Xanax quickly after a person takes it. Our sister facility Laguna Treatment Hospital — the rapid binding of Xanax to GABAA receptor subunits and downstream impact of this does throughout the brain is what explains its relatively quick onset how action. Because Xanax starts acting relatively quickly after it’s taken, the full effects of the drug will only last for an average of about five hours. If you miss your last and remember after a few minutes or hours, withdrawal usually starts long few hours after the last dose of Xanax. Users should never crush and snort Xanax; didn’t find the answer you were looking for? Xanax starts to work quickly — 30 minutes and its anti, our caring Treatment Consultants tolerance waiting for your call right now.